Anti-FOXL2 antibody produced in rabbit, affinity isolated antibody

Synonyms: Anti-Forkhead L2; Anti-Forkhead Transcription Factor

MDL No.: MFCD09039192

Storage: -20C

UNSPSC Code: 12352203

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Application: Anti-FOXL2 antibody produced in rabbit is suitable for the following applications: . Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 0.2μg/mL using murine prenatal folicle . Indirect immunofluorescence at a concentration of 2μg/mL using KK1 granulosa cells . Western blotting (at a concentration of 0.2μg/mL using CHO whole cell lysate) or immunoblot analysis.

Biochem/physiol Actions: Forkhead box protein L2 is a protein encoded by the FOXL2 gene in humans. The gene FOXL2 encodes a member of the fork-head-winged-helix family of transcription factors. It is expressed early during female gonadal development and is expressed in normal ovarian stroma and ovarian neoplasms with granulosa cell lineage. FOXL gene encodes an essential transcription factor in the ovary and helps in female sex determination, follicle recruitment and granulosa cell development. Its mutation is specific to AGCTs in the ovary and is useful for diagnosis of disease. FOXL2 acts as an oncogene or tumour suppressor depending on the genetic context that is the GCT subtype.

Immunogen: synthetic peptide M(1)MASYPEPEDTAGT(14) corresponding to amino acid residues 1-14 from mouse FOXL2. This sequence is completely conserved in mouse and rat and 92% conserved in human.

Physical form: Provided as 100 mug of affinity purified IgG (1 mg/mL) in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide.

Target description: FOXL2 encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.