MDL No.: MFCD03791550
Storage: -20C
UNSPSC Code: 12352203
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General description: FOXO3a is member of the Forkhead transcription factor superfamily and functions to protect cells from oxidative stress . Dephosphorylation of FOXO3a stimulates the Fas ligand gene that activates apoptosis in cells . Anti-FKHRL1 is specific for human and mouse FKHRL1. FKHRL1 immunizing peptide specifically inhibits the staining of FKHRL1.
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)
Application: Anti-FKHRL1 (FOXO3a) antibody is suitable for use in microarray, immunoblot (70-75 kDa), western blot (1:2,500 using human FKHRL1 in transfected 293T cell extracts) and indirect immunofluorescence (1:200 using paraformaldyde-fixed FKHRL1 transfected 293T cells). An additional band at 35 kDa may be observed in some preparations.
Immunogen: thetic peptide corresponding to the N-terminus of human FKHRL1 (amino acids 653-668 with N-terminally added cystein) conjugated to maleimide-activated KLH. This sequence is conserved in human and mouse FKHRL1.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 15 mM sodium azide.