Synonyms: Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A; Anti-MBN/MNBH; Anti-MNB protein kinase; Anti-Minibrain Drosophila homolog
Storage: -20C
UNSPSC Code: 12352203
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General description: The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.
Application: Anti-DYRK1A (N-terminal) antibody produced in rabbit is suitable for western blotting at a working concentration of 1.5-3 mug/mL using rat brain embryonic extract (S1 fraction) and 3-5 mug/mL using PC12 cell lysate.
Biochem/physiol Actions: DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.
Immunogen: synthetic peptide corresponding to amino acids 32-51 of human DYRK1A, conjugated to KLH. This sequence is identical in human DYRK1A isoforms 1-5, and highly conserved (single amino acid change) in rat Dyrk1a and mouse Dyrk1a (90% identity).
Physical form: Solution in 0.01 M phosÂphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Target description: DYRK1A (N-terminal) encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-c
RIDADR: NONH for all modes of transport