Synonyms: Anti-ADAP78; Anti-Calcipressin 1; Anti-DSC1; Anti-Down Syndrome Candidate Region 1; Anti-MCIP1; Anti-Myocyte-enriched calcineurin-interacting protein 1; Anti-RCAN1; Anti-RCN1; Anti-Regulator of calcineurin 1
Storage: -20C
UNSPSC Code: 12352203
Features and Benefits: Antibody BioguaranteeEvaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description: Down Syndrome Candidate Region 1 or DSCR1 is a candidate gene involved in the pathogenesis of Down's Syndrome (DS). DSCR1 is usually expressed in cardiac, skeletal and brain tissues, whereas its overexpression in fetal brain tissues is associated with DS. DSCR1 inhibits calcineurin-mediated mRNA synthesis . Anti-DSCR1 (C-terminal) antibody is specific for DSCR1 in rats, mice and humans. The immunizing peptide specifically inhibits the staining of DSCR1 by immunoblotting.
Application: Anti-DSCR1 (C-terminal) antibody is suitable for use in western blot (2-4 mug/mL using HEK-293T cells expressing human DSCR1) and in immunoblotting (approx. 26 kDa).
Immunogen: synthetic peptide corresponding to amino acids 235-252 of human DSCR1, conjugated to KLH. This sequence is identical in human DSCR1 isoforms a and b, and rat and mouse DSCR1.
Physical form: Solution in 0.01 M phosÂphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport