Anti-Dopamine Transporter, Extracellular Loop 2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

Synonyms: Anti-DAT

MDL No.: MFCD02262815

Storage: -20C

UNSPSC Code: 12352203

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Application: Anti-Dopamine Transporter, Extracellular Loop 2 antibody produced in rabbit is suitable at a working dilution of 1:1000 for western blotting using SDS-solubilized human striatal samples and for immunohistochemistry using formaldehyde-fixed human and monkey brain sections.

Biochem/physiol Actions: The dopamine transporter (DAT1) acts to take released dopamine back up into presynaptic terminals and has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse. DAT1 gene is a primary target gene for ADHD (Attention deficit hyperactivity disorder). DAT polymorphism along with maternal prenatal smoking is associated with childhood hyperactivity-impulsivity and inattentiveness.

Immunogen: synthetic peptide from the extracellular loop 2 region of human dopamine transporter.

Physical form: Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 mug/mL BSA, and 50% glycerol.

Target description: The dopamine transporter (DAT1) acts to take released dopamine back up into presynaptic terminals and has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse.