Synonyms: Anti-Cleavage stimulation factor, 3-prime PRE-RNA, subunit 1, 50-KD; Anti-CstF-50; Anti-CstFp50
Storage: -20C
UNSPSC Code: 12352203
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Application: Anti-CSTF1 (C-terminal) antibody produced in rabbit is suitable for immunoprecipitation at a working amount of 5-10mug using K562 lysates and western blotting at a concentration of 2-4mug/mL using K562 lysates.
Biochem/physiol Actions: Cleavage stimulation factor (50kDa) subunit is a protein encoded by the CSTF1 gene in humans. It is one of the multiple factors that plays a significant role during polyadenylation of mammalian pre-mRNAs. The mRNA polyadenylation factor CstF interacts with the BRCA1-associated protein BARD1 resulting in repression of the nuclear mRNA polyadenylation machinery. It participates in the regulation of endogenous transcripts during DNA-damage.
Immunogen: synthetic peptide corresponding to amino acids 418-431 of human CSTF1, conjugated to KLH. The corresponding sequence is identical in mouse and rat.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.