Anti-Cannabinoid Receptor 1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

MDL No.: MFCD01633082

Storage: -70C

UNSPSC Code: 12352203

General description: Cannabinoid receptor type 1 (CNR1) is a G protein-coupled cannabinoid receptor found in central and peripheral nervous system. CNR1 belongs to rhodopsin-like G protein-coupled receptor superfamily.

Application: Anti-Cannabinoid Receptor 1 antibody produced in rabbit is suitable for immunocytochemistry and immunohistochemistry using formalin-fixed and paraffin-embedded sections at a concentration of 8-11mug/mL.

Biochem/physiol Actions: CNR1 has implications in several disease states, including drug addiction, anxiety, depression, obesity, and chronic pain. Different classes of CNR1 agonists are involved in signaling pathways through the activation of specific subtypes of G proteins. It may play a key role for the treatment of negative affective state produced by alcohol withdrawal and abstinence which is critical for the maintenance of alcohol addiction. CNR1 genes also play some roles in common polymorphism (rs1049353) with potential implications in weight loss.

Immunogen: synthetic peptide corresponding to the third cytoplasmic loop of human cannabinoid receptor 1, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.

Physical form: Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.