Anti-Cannabinoid Receptor 1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

MDL No.: MFCD01633082

Storage: -20C

UNSPSC Code: 12352203

Application: Anti-Cannabinoid Receptor 1 antibody produced in rabbit is suitable for western blotting at a working dilution of 1:250 and for immunocytochemistry at a working dilution of 1:1000.

Biochem/physiol Actions: Cannabinoids exert their well-known physiological effects through two G-protein coupled receptors, CB1 and CB2. The cannabinoid receptor type 1 (CB1) is widely distributed in mammalian tissues, with the highest concentrations found in brain neurons while CB2 receptor function primarily in the peripheral immune system, found in spleen and may be present in the central nervous system, including the retina. The cannabinoid receptor type 1 are involved in modulation of adenylate cyclase and ion channels. It is also involved in the modulation of nociception, movement, learning and memory, emotion and many other neuronal processes. It also plays an essential role in drug addiction. CB1 receptor blockade may be useful for treatment of angiotensin II-dependent hypertension and associated metabolic syndrome.

Immunogen: fusion protein containing amino acids 1-99 of the human CB1 receptor.

Physical form: Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin, 50% glycerol, and 0.05% sodium azide.