Synonyms: ActRIIB
MDL No.: MFCD01864596
Storage: -20C
UNSPSC Code: 51111800
General description: Activin is a disulfide-linked dimeric protein released by grandulosa cells in the ovary and sertoli cells in the testis. Activin Receptor IIB belongs to Ser/Thr protein kinase family and can transduce the activin signal from the cell surface to the cytoplasm. Activin will not bind directly to Type I activin receptors rather it will associate with the type II receptor-activin complex and start signal transduction. Many ligands signal through Activin Receptor IIB can regulate muscle growth. Anti-Activin Receptor IIB antibody can be used in flow cytometry and immunohistochemistry. Goat Anti- Activin Receptor IIB antibody reacts specifically with recombinant human activin receptor IIB. The product has shown no cross-reactivity for human activin receptor IA, recombinant human activin receptor IIA or recombinant human activin receptor IB.
General description: Anti-Activin Receptor IIB recognizes recombinant human activin receptor IIB by methods such as immunoblotting and ELISA. The antibody can inhibit receptor-ligand interaction. In ELISA assays, the antibody can block 50% of the binding of recombinant human activin A to recombinant human activin receptor IIB/Fc chimera. Furthermore, the antibody exhibits 15% cross-reactivity with recombinant human activin receptor I. This antibody shows no cross reactivity with recombinant human activin receptor IA, IIA, and IB using ELISA and immunoblotting methods.
Application: Goat anti-activin receptor IIB antibody can be used for immunohistochemistry (5 mug/mL) and flow cytometry (10 muL) applications.
Application: Anti-Activin Receptor IIB can be used in western blotting (working concentration-0.1-0.2 mug/mL) for detecting human activin receptor IIB.
Immunogen: purified, NSO-derived, recombinant human activin receptor IIB extracellular domain.
Physical form: Lyophilized from a 0.2 mum filtered solution in phosphate buffered saline containing 5% trehalose
RIDADR: NONH for all modes of transport
WGK Germany: 3