Synonyms: ATP-gamma-S; Adenosine 5'-(3-thiotriphosphate) tetralithium salt; Ado-5'-PPP[S]
CAS Number: 93839-89-5
Formula: C10H12Li4N5O12P3S
Formula Weight: 546.98
Linear Formula: C10H12Li4N5O12P3S
MDL No.: MFCD00077293
Purity: >=75%
Storage: -20C
Beilstein Registry Number: 6265083
EC Number: 298-862-8
UNSPSC Code: 41106305
Application: Adenosine 5'-[gamma-thio]triphosphate (ATP-gamma-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- gamma-S is a P2 purinergic agonist which increases the activity of Ca2+-activated K+ channels. ATP- gamma-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-gamma -S differentially modulates Toll-like receptor 4-mediated cell survival and death.
Biochem/physiol Actions: P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases.
Other Notes: Non-hydrolyzable ATP analog
RIDADR: NONH for all modes of transport
WGK Germany: 3
R Codes: 36/37/38
S Codes: 26-36
IOD Codes: Xi