Synonyms: 116-9e; 4-[1,1'-Biphenyl]-4-yl-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]-1(2H)-pyrimidinehexanoic acid
CAS Number: 831217-43-7
Formula: C31H32N2O5
Formula Weight: 512.6
Linear Formula: C31H32N2O5
MDL No.: MFCD18632539
Purity: >=98% (HPLC)
Storage: 2-8C
UNSPSC Code: 12352200
Biochem/physiol Actions: 116-9e is a blocker of Hsp40-Hsp70 binding thereby inhibiting the chaperone activity of Hsp70-Hsp40. The Hsp40 family of co-chaperones binds to Hsp70 through a conserved J-domain. It is believed that 116-9e inhibits chaperone functions by preventing Hsp70-Hsp40 complex assembly.The same compound by a different name, MAL2-11B, has been found to inhibit the activity of a viral J-domain protein, large tumor antigen (TAg). MAL2-11B inhibited both TAg's endogenous ATPase activity and the TAg-mediated activation of Hsp70.
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
R Codes: 25-50/53
S Codes: 45-60-61
IOD Codes: T,N
Symbol: GHS06, GHS09
Signal Word: Danger
Hazard Statements: H301-H410
Precautionary statements: P273-P301 + P310-P501