Synonyms: 1,8-Diamino-3,6-di-1-pyrrolidinyl-2,7-naphthyridine-4-carbonitrile; MLS000054131; MiR-544 Inhibitor 1
Molecular Formula: C17H21N7
Molecular Weight: 323.4
Linear Structural Formula: C17H21N7
MDL Number: MFCD03483890
Purity: >=95% (HPLC)
Storage: room temp
Biochem Physiol Actions: SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1alpha, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2'-O-methyl RNA antagomir.
Other Notes: light sensitive