Synonyms: 4-fluoro-alpha-(4-fluorophenyl)-alpha-phenyl-Benzeneacetamide; ICA 17043
Molecular Formula: C20H15F2NO
Molecular Weight: 323.34
Linear Structural Formula: C20H15F2NO
MDL Number: MFCD09027349
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Senicapoc (ICA-17043) is an inhibitor of the calcium-activated K+ channel KCa3.1, also known as the Gardos channel, which plays a role in K+ loss and dehydration of sickled red blood cells. Senicapoc blocks calcium-induced rubidium flux in human RBCs with and IC50 of 11 nM and prevents RBC dehydration in a transgenic mouse sickle cell disease model. It has been investigated for a number of possible uses, which include antimalarial activity, idiopathic pulmonary fibrosis, glioblastoma, lung cancer, non-alcoholic liver disease, hereditary xerocytosis, suppression of microglial activation in stroke, and immune system disorders.