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MilliporeSigma

SBI-0640756 >=98% (HPLC)

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SBI-0640756 >=98% (HPLC)

Synonyms: 6-Chloro-3-[3-(5-fluoro-pyridin-3-yl)-acryloyl]-4-phenyl-1H-quinolin-2-one; SBI-756

Molecular Formula: C23H14ClFN2O2

Molecular Weight: 404.82

Linear Structural Formula: C23H14ClFN2O2

Purity: >=98% (HPLC)

Storage: 2-8C

Biochem Physiol Actions: SBI-0640756 is a potent inhibitor of eIF4G1 that disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.

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Product Detail
Thomas No.
CHM03J336
Mfr. No.
SML1645-5MG
Description
SML1645-5MG, SBI-0640756 >=98% (HPLC)
Packaging Size
5 mg
list price/quantitytotal
$0.00
$0.00 (0 Items)
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