A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that induce both differentiation of transformed cells and apoptosis. Shown to suppress the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively).
Synonyms: SBHA - CAS 38937-66-5 - Calbiochem; Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
Molecular Formula: C8H16N2O4
Molecular Weight: 204.22
Linear Structural Formula: C8H16N2O4
MDL Number: MFCD00192455
Purity: >=98% (TLC)
Biochem Physiol Actions: Target IC50: 11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively
Legal Information: Not available for sale in the United States.
Other Notes: Brinkmann, H., et al. 2001. J. Biol. Chem.276, 22491.Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 5705.Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA91, 10251.