Synonyms: (+/-) (3R*,5S*)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid; SB 201076 prodrug; SB 204990; SB-201076 prodrug; SB201076 prodrug; SB204990
Molecular Formula: C18H22Cl2O5
Molecular Weight: 389.27
Linear Structural Formula: C18H22Cl2O5
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: SB-204990 is a cell-permeable and orally available gamma-lactone prodrug of the non-cell-permeable SB-201076 that inhibits human and rat ATP citrate-lyase (Ki =1 muM against human and rat ACL) in a predominantly competitive manner with a small but significant uncompetitive component. SB-204990 treatment is shown to suppress the rate of cellular cholesterol and fatty acid synthesis in HepG2 cultures (by 91% & 82%, respectively, with 30 muM SB-204990), and display hypocholesterolaemic and hypolipidaemic efficacy in vivo when administered in the diet (0.05-0.25%, w/w; mice, rats, dogs).