SARS-CoV-2 belongs to Coronaviridae (CoVs) - a large family of viruses that usually cause mild to moderate upper-respiratory tract diseases.1 CoVs are single-stranded RNA viruses. They have a high mutation rate and are therefore highly diverse.1 Their hosts include human and non-human mammals, as well as birds.1
Synonyms: COVID-19; SARS-CoV-2; Spike Protein RBD; Spike-ACE2; coronavirus
Purity: >=95% (SDS-PAGE)
Storage: -20C
Application: The activity of this product is tested by a functional ELISA. Immobilization of Spike protein Receptor Binding Domain at 2 mug/mL (100 muL/well), allows binding of ACE2, biotin tagged (Cat. No. SAE0171). The half maximal binding (binding which produces 50% of the optimal binding response) is <=2 mug/mL.
Biochem Physiol Actions: SARS-CoV-2 infects cells which express angiotensin converting enzyme 2 (ACE2).2 ACE2 binds to the viral envelope-associated spike (S) protein as a cellular receptor, following proteolytic cleavage of both S and ACE2 by serine proteases.3 The receptor binding domain (RBD) of S protein is the domain that specifically binds to ACE2.