SAMS Peptide trifluoroacetate salt is a peptide having a putative AMPK phosphorylation site (Ser568) of carbohydrate-responsive element-binding protein (ChREBP) and a peptide containing a cAMP-dependent protein kinase (PKA) phosphorylation site (Thr666).
Synonyms: HMRSAMSGLHLVKRR trifluoroacetate salt; His-Met-Arg-Ser-Ala-Met-Ser-Gly-Leu-His-Leu-Val-Lys-Arg-Arg-OH trifluoroacetate salt; L-Histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-seryl-glycyl-L-leucyl-L-histidyl-L-leucyl-L-valyl-L-lysyl-L-arginyl-L-arginine trifluoroacetate salt
Molecular Formula: C74H131N29O18S2 · xC2HF3O2
Linear Structural Formula: C74H131N29O18S2 · xC2HF3O2
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: SAMS Peptide is a synthetic substrate selective for AMP-activated protein kinase (AMPK). Its sequence is based on acetyl-CoA carboxylase, which is phosphorylated exclusively by the AMPK, but with serine (Ser)-79 replaced by alanine SAMS peptide is more specific for AMPK than acetyl-CoA carboxylase itself.