Synonyms: 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride; AGY 94806; AGY94806; Cutamesine; SA 4503
Molecular Formula: C23H32N2O2 · 2HCl
Molecular Weight: 441.43
Linear Structural Formula: C23H32N2O2 · 2HCl
MDL Number: MFCD09842336
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: SA4503 is a high affinity, orally active non-opioid intracellular receptor sigma-1 (sigma1R) selective agonist (IC50 = 17.4 nM against 200 nM (+)-pentazocine for binding sigma1R), exhibiting ~100-fold less affinity for the sigma 2 receptor subtype (sigma2R) and little or no affinity toward 36 other receptors, ion channels and second messenger systems. Oral administration is reported to elicit cerebral acetylcholine (ACh) release in rat frontal cortex and hippocampus (5-20 mg/kg p.o.) and reduce immobility time in a mouse forced swimming test (Immobility time = 214.8 s without vs. 111.6 s with 1.0 mg/kg oral dosage).