Antigen: human S1P1 amino acids 241-253
Host: rabbit
Cross Reactivity: (+) human, mouse, porcine, and rat S1P1
Application(s): ICC, IHC (formalin-fixed paraffin-embedded tissue), and WB
S1P exerts its activity by binding to five distinct GPCRs, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 primarily mediates S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells suggesting diverse physiological functions of this receptor.