Synonym: (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, Levosulpiride
CAS Number: 23672-07-3
Empirical Formula (Hill Notation): C15H23N3O4S
Molecular Weigh:t 341.43
MDL number: MFCD00055220
PubChem Substance: ID 24278709
Biochem/physiol Actions
D2 dopamine receptor antagonist; antipsychotic.
(S)-(-)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients. Since dopamine controls human sexual function, (S)-(-)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.
Application
(S)-(-)-Sulpiride was used to study the effect of dopamine D2 receptor function on activation of KCNQ potassium channels and on depression-like behavior in ovariectomized female rats.
assay: =98% (titration)
mp: 183-186 °C(lit.)
storage temp.: 2-8°C