CAS Number: 2114454
Formula: C20H16N2O4
Formula Weight: 348.35
Linear Formula: C20H16N2O4
MDL No.: MFCD00081076
Purity: >=90% (HPLC)
Melting Point: 260 C (dec.) (lit.)
Storage: 2-8C
Beilstein Registry Number: 631069
UNSPSC Code: 12352200
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Biochem/physiol Actions: (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
Other Notes: 20S isomer
RTECS: UQ0492000
RIDADR: UN 1544PSN1 6.1 / PGIII
WGK Germany: 3
R Codes: 25
S Codes: 45
IOD Codes: T
Symbol: GHS06
Signal Word: Danger
Hazard Statements: H301
Precautionary statements: Missing Phrase - N15.00950417