Synonym: Quercetin-3-rutinoside hydrate, Vitamin P hydrate
CAS Number: 207671-50-9
Empirical Formula (Hill Notation): C27H30O16 · xH2O
Molecular Weight: 610.52 (anhydrous basis)
Beilstein Registry Number: 75455
EC Number: 205-814-1
MDL Number: MFCD01319140
PubChem Substance ID: 24899379
Biochem/physiol Actions
A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase ß and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.
Assay: =94% (HPLC)
Form: powder
Color: yellow to green
MP: 195 °C (dec.)(lit.)
Solubility: pyridine: soluble50 mg/mL; DMSO: soluble; aqueous base: soluble