Synonyms: 1,1'-[[1,1'-Biphenyl]-4,4'-diylbis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium dibromide (9CI); 1,1'-[[[1,1'-Biphenyl]-4,4'-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium] bromide; RSM 932A; TCD-717
Molecular Formula: C46H38Cl2N4 · 2Br
Molecular Weight: 877.53
Linear Structural Formula: C46H38Cl2N4 · 2Br
Purity: >=97% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: RSM932A is a potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells via prolonged activation of ER stress response and C/EBP homologous protein (CHOP) overproduction. RSM932A decreases de novo in phosphatidylcholine synthesis and increases ceramides levels that selectively trigger apoptosis in cancer cells. On the other hand, RSM932A induces reversible G0/G1 cell cycle arrest in nontumorigenic cells. RSM932A exhibits potent antiproliferative activity in array of human cancer cell lines.