Synonyms: 1-(4-Amino-5-chloro-2-methoxy-phenyl)-3-[1(n-butyl)-4-piperidinyl]-1-propanone hydrochloride; 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone hydrochloride; RS-67,333 hydrochloride; RS-67333 hydrochloride; RS67333 hydrochloride
Molecular Formula: C19H29ClN2O2 ·HCl
Molecular Weight: 389.36
Linear Structural Formula: C19H29ClN2O2 ·HCl
MDL Number: MFCD00938576
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: RS 67333 is a selective, high affinity (pKi = 8.7 for the 5-HT4 binding site in guinea-pig striatum) partial agonist toward 5-HT4 receptor that relaxes carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pEC50/%reversal = 8.7/50 with RS 67333 vs. 8.2/100 with 5-HT) and induces tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (ED50 via i.p. in mug/kg over max heart rate increase in beats/min = 4.9/35 with RS 67333 vs. 3.2/95 with 5-HT). RS 67333 is also reported to show high affinity for sigma receptors (pKi = 8.9/sigma1 and 8.0/sigma2), while exhibiting much reduced affinity toward a panel of other receptors, including 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3 (pKi<6.4 ), muscarinic receptors (pki="5.2/M1" & 5.3 2), and adrenoceptors (pki <6.7 for alpha1a, alpha1b, alpha2a, alpha2b, beta1, beta2).<>