Synonym: (E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrim idin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid, calcium salt (2:1), Rosuvastatin hemicalcium
CAS Number: 147098-20-2
Empirical Formula (Hill Notation): C22H27FN3O6S · 0.5 Ca
Molecular Weight: 500.57
Biochem/physiol Actions
Rosuvastatin calcium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin calcium is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
Assay: ≥98% (HPLC)
Form: powder
Optical Activity: [α]/D +12 to +18°, c = 1 in methanol: water (1:1)
Storage Condition: desiccated
Color: white to beige
Solubility: DMSO: soluble10 mg/mL, clear
Storage Temp.: 2-8°C