Anti-inflammatory, insecticidal, and anticancer tetrahydrobenzofuran isolated from Aglaia species that inhibits TNF-α, NF-κB, NF-AT and various cytokines (IFN-γ, TNF-α, IL-2, and IL-4) with IC50 values in the nanomolar range; induces apoptosis in human leukemia cell lines, activating p38 MAPK/JNK and suppressing ERK.