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MilliporeSigma

RI(dl)-2 >=98% (HPLC)

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RI(dl)-2 >=98% (HPLC)

Synonyms: N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline

Molecular Formula: C19H17N3 · xC2HF3O2

Linear Structural Formula: C19H17N3 · xC2HF3O2

Purity: >=98% (HPLC)

Storage: 2-8C

Biochem Physiol Actions: RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 muM) without affecting its ssDNA-binding activity (IC50 >100 muM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 muM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

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Product Detail
Thomas No.
CHM02Y705
Mfr. No.
SML1851-5MG
Description
SML1851-5MG, RI(dl)-2 >=98% (HPLC)
CAS Number
1902146-75-1 (free base)
list price/quantitytotal
$0.00
Thomas No.
CHM02Y706
Mfr. No.
SML1851-25MG
Description
SML1851-25MG, RI(dl)-2 >=98% (HPLC)
CAS Number
1902146-75-1 (free base)
list price/quantitytotal
$0.00
$0.00 (0 Items)
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