Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 (sirtuin 1) activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Inhibitor of NLRP3 inflammasome activation.
Purity: >98% (HPLC)
Appearance: Off-white to greyish powder
Source: Isolated from Polygonum cuspidatum