Synonyms: alphaR-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamide; (R)-(-)-N-2-[(4-Isobutylphenyl)propionyl]methanesulfonamide; DF 1681Y; Repertaxin
Molecular Formula: C14H21NO3S
Molecular Weight: 283.39
Linear Structural Formula: C14H21NO3S
MDL Number: MFCD18633292
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Reparixin is a noncompetitive allosteric inhibitor of the inflammatory CXCL8 (IL-8) chemokine receptors CXCR1 and CXCR2 with IC50 values of 1 nM for CXCR1 and 100 nM for CXCR2. It is believed to prevent receptor signaling by locking CXCR1/R2 in an inactive conformation. Reparixin has been studied to prevent ischaemia-reperfusion injury and inflammation and is clinical trials for triple negative breast cancer and to prevent injury occurring after pancreatic islet transplantation.