The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates thisinteraction.The S protein plays key parts in the induction of neutralizing-antibody and T-cellresponses, as well as protective immunity.Recombinant SARS-COV-2 S1+S2 ECD (S-ECD) Protein with His tag (Wild type, pre-fusion state plus post-fusion state) is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val11-Gln1208) of SARS-COV-2(2019-nCoV) S1+S2 ECD (S-ECD) (Accession #YP_009724390.1) fused with a 6XHis tag at the C-terminus.
Synonyms: 2019-nCoV S glycoprotein; 2019-nCoV coronavirus spike Protein; 2019-nCoV ncov spike Protein; COVID-19 S protein; Spike glycoprotein; cov spike Protein
Purity: >97% (SDS-PAGE)
Storage: -70C
Biochem Physiol Actions: Measured by its binding ability in a functional ELISA. Immobilized Recombinant SARS-COV-2 Spike S1+S2 ECD-His at 2mug/mL (100 muL/well) can bind Recombinant Human ACE2 with a linear range of 0.15-9.92 ng/mL.