Synonyms: 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
Molecular Formula: C25H20N4O3
Molecular Weight: 424.45
Linear Structural Formula: C25H20N4O3
MDL Number: MFCD03341241
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: RBC8 is a selective inhibitor of the Ras-like GTPases RalA and RalB, downstream mediators of Ras signalling, without direct inihibition of Ras or RhoA activity. RBC8 binds to a site on the GDP-bound form of Ral, its inactive state, inhibiting the binding of Ral to its effectors, such as Ral-binding protein 1 (RALBP1; also known as RLIP760, which are involved in proliferation, survival, and metastasis of several human cancers. RBC8 inhibited growth in human luung cancer cell lines with IC50 values of 2.0 muM in H2122 cells and 1.3 muM in H358 cells, and also inihbited tumor xenograft growth..