Synonyms: 2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide; N-(2, 3-Dichlorobenzylideneamino) guanidine; Rational inhibitor of a holophosphatase1
Molecular Formula: C8H8Cl2N4
Molecular Weight: 231.08
Linear Structural Formula: C8H8Cl2N4
MDL Number: MFCD03653280
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Raphin1 is an orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B). It does not inhibit PP1c. Raphin1 transiently decreases protein synthesis in cells. It is efficacious in mouse model of Huntington's disease.