Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor.
Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited, possibly through the inhibition of the Akt pathway. Induces autophagy in yeast and mammalian cell lines.
Rapamycin binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
Purity: ≥98%
Key Applications: Antibiotic, Anticancer agent, Immunosuppressant
Application Areas: Antibiotic, anticancer agent, immunosuppressant
Product Type: Biochemicals
Chemical Class: Pharmaceuticals
Extinction Coefficient (E1%): E1 %, 1 cm (maximum wavelength, 95% ethanol) is: 417 (267 nm); 541 (277 nm); 416 (288 nm)(Lit.)
Presentation: White powder
Format: Powder
Solubility: Soluble in ether, chloroform, acetone,DMF, methanol (25 mg/mL - clear, colorless solution) or DMSO; very sparingly soluble in hexane and petr ether; insoluble in water.
Storage & Handling: Store at -20°C.