Synonyms: (3R)-2'-[(4-Bromo-2-fluorophenyl)methyl]-spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone.; AS-3201
Molecular Formula: C17H11BrFN3O4
Molecular Weight: 420.19
Linear Structural Formula: C17H11BrFN3O4
MDL Number: MFCD00920915
Purity: >=97% (HPLC)
Storage: -20C
Biochem Physiol Actions: Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirestat has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirestat prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy.