Synonyms: Z-L-Leu-D-Leu-L-Leu-al
CAS Number: 1211877-36-9
Formula: C26H41N3O5
Formula Weight: 475.62
Linear Formula: C26H41N3O5
Purity: >=98% (HPLC)
Storage: -20C
UNSPSC Code: 12352200
Application: (R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.
Biochem/physiol Actions: MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.
RIDADR: NONH for all modes of transport
WGK Germany: 3