Synonyms: (R)-5-Chloro-N-[4-(4-methylpiperazin-1-yl)phenyl]-N'-[(tetrahydrofuran-2-yl)methyl]pyrimidine-2,4-diamine mesylate; (R)-9b mesylate; 5-Chloro-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N4-[[(2R)-tetrahydro-2-furanyl]methyl]-2,4-pyrimidinediamine
Molecular Formula: C21H31ClN6O4S
Molecular Weight: 499.03
Linear Structural Formula: C21H31ClN6O4S
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: (R)-9bMS is a potent and selective inhibitor of ACK1 (TNK2) tyrosine kinase that exhibits potent anticancer activity. (R)-9bMS attenuates AR and AR-V7 expression in prostate cancer cells. (R)-9bMS potently inhibits triple negative breast cancer (TNBC) cells proliferation.