This product is recombinant human PKM2 (P14618) expressed in E. coli and has a predicted molecular mass of 58 kDa. The embryonic pyruvate kinase M2 (PKM2) is one of the isoforms of pyruvate kinases (PK), found in mammals. It is coded by the PKM2 gene mapped to human chromosome 15q23. PKM2 is expressed in all cells excluding adult muscle, brain and liver. This protein is usually present as an active tetrameric form.
Synonyms: Cytosolic Thyroid hormone-binding protein (CTHBP); M2-PK; OPA-interacting protein 3 (OIP-3); PKM2; Pyruvate kinase 3 (PK3); Pyruvate kinase muscle isozyme; p58
Storage: -20C
Application: Human pyruvate kinase M2 (PKM2) has been used to study the effects of phosphorylated PKM2 in inactivating myofibroblasts during renal fibrosis.
Biochem Physiol Actions: Pyruvate kinase (PK) is an important glycolytic enzyme catalyzing the last step of glycolysis, transferring a phosphate group from phosphoenolpyruvate to ADP to yield one molecule of ATP and one molecule of pyruvate.The embryonic pyruvate kinase M2 (PKM2) controls ß-catenin transactivation. It plays an important role in aerobic glycolysis or the Warburg effect. PKM2 induces gene transcription and tumorigenesis.