Synonyms: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-benzenesulfonamide
Molecular Formula: C18H13F6N3O2S
Molecular Weight: 449.37
Linear Structural Formula: C18H13F6N3O2S
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3. Pyr10 blocks carbachol-induced calcium entry into TRPC3-transfected HEK293 cells (IC50 = 0.72 muM), with significantly lower activity against STIM1/Orai1 mediated release of calcium from endoplasmic reticulum (store operated calcium entry) in BRL-2H3 cells (IC50 = 13.08 muM).