Synonyms: (SP-4-2)-Chloro[4'-(4-methylphenyl)-2,2':6',2''-terpyridine-kappaN1,kappaN1',kappaN1'']-Platinum(1+) chloride; Tolylterpyridin-platin
Molecular Formula: C22H17Cl2N3Pt
Molecular Weight: 589.37
Linear Structural Formula: C22H17Cl2N3Pt
Purity: >97% (NMR)
Storage: 2-8C
Biochem Physiol Actions: Pt-ttpy, a metallo-organic complex, is a G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).