Protector Combination Glove Boxes provide an enclosed environment for handling both hazardous substances and atmosphere-sensitive materials. These glove boxes have a HEPA inlet filter to provide a particulate-free internal environment. Closure of two internal valves converts the box to a controlled atmosphere glove box that can be pressurized up to ±5 inches water gauge achieving a leak-tight inert atmosphere. When atmosphere-sensitive procedures are complete, opening the two internal valves allows air from inside the box to pass through a HEPA outlet filter and optional second HEPA or carbon outlet filter before exhausting via ductwork to the outside. The physical barrier and filtration system of these boxes protect the user from exposure to hazardous materials.