Synonyms: H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH trifluoroacetate salt; Prosaptide trifluoroacetate salt; TX14(A) trifluoroacetate salt; TXLIDNNATEEILY (Modifications: Ala-2 = D-Ala) trifluoroacetate salt; TaLIDNNATEEILY trifluoroacetate salt
Molecular Formula: C69H110N16O26 · xC2HF3O2
Linear Structural Formula: C69H110N16O26 · xC2HF3O2
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: Prosaptide Tx 14(A) is a potent agonist of G protein-coupled receptors GPR37 (also known as Parkin-associated endothelin receptor-like receptor Pael-R) and GPR37L1. Prosaptide Tx 14(A) is the active fragment of prosaposin, a secreted neuroprotective and glioprotective factor. Prosaptide Tx 14(A) has EC50 values of 5 nM for GPR37L1 and 7 nM for GPR37, and has also been shown to have some GSK3 inhibitory properties. Prosaptide has been shown to improve nerve regeneration in diabetic rats, to reduce neuropathic pain, and to protect dopaminergic neurons in animal models of Parkinson disease.