Synonyms: 25,28,29 TriPro-amylin (human) acetate; AC 0137; AC 137; AC0137; AC137; TriPro-amylin acetate; [Pro25,28,29]-amylin (human) acetate
Molecular Formula: C171H267N51O53S2
Molecular Weight: 3949.39
Linear Structural Formula: C171H267N51O53S2
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: Pramlintide (AC0137, AC137, triPro-amylin) is a synthetic antidiabetic peptide that corresponds to human amylin (aa34-70) with proline substitutions at N25, S28 and S29 to limit the self-aggregation seen with native amylin. Pramlintide augments endogenous amylin-mediated glycemic control (blood glucose regulation) in vivo by delaying gastric emptying and inhibiting the secretion of glucagon, a catabolic hormone that opposes the effects of insulin and amylin.