Synonyms: (2S)-N1-[2-[([1,1'-biphenyl]-3-ylcarbonyl)amino]ethyl]-N4-(1,1-dimethylethyl)-2-[(1-oxo-3-phenylpropyl)amino]-butanediamide
Molecular Formula: C32H38N4O4
Molecular Weight: 542.67
Linear Structural Formula: C32H38N4O4
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: PKS21004 is highly selective, potent and reversible inhibitor of the Plasmodium falciparum proteasome (Pf20S) beta5 subunit. It is not active against mammalian c-20S and i-20S proteasome subunits. PKS21004 is effective against erythrocytic, sexual, and liver-stage parasites. Also it is active against parasites resistant to current antimalarials, and strains from patients in Africa.