Synonyms: 5-Chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid
Molecular Formula: C6H5ClN2O4S
Molecular Weight: 236.63
Linear Structural Formula: C6H5ClN2O4S
MDL Number: MFCD00507244
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. Additionally independently from p53, PK11007 impairs reactive oxygen species (ROS) detoxification in a number of mutant p53 cancer cells. PK11007 exhibits anticancer activity in number of cancer cell lines while shoving low cytotoxicity toward normal cells.