Synonyms: 1-[1-[6-([1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
Molecular Formula: C29H32N4O2
Molecular Weight: 468.59
Linear Structural Formula: C29H32N4O2
MDL Number: MFCD28396418
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP was found to act as a respiratory stimulant, stimulating breathing in isoflurane-anesthetized rats.