Phorbol 12-myristate 13-acetate (PMA) can induce the activity of PLD1 (phospholipase D1) but not PLD2 (phospholipase D2).Through the protein kinase C (PKC) signaling pathway, PMA is a tumor promoter associated with:
•gene transcription
•cell growth
•cell differentiation
•programmed cell death
•immune pathway
•receptor desensitizationPhorbol 12-myristate 13-acetate is used to study:
•growth factors
•hormones
•cytokines-mediated regulation of cellular growth and differentiation
Synonyms: Phorbol 12-myristate 13-acetate; NF-kappaB Activator; PKC Activator; croton oil; phorbol ester; protein kinase C activator; 12-O-Tetradecanoylphorbol 13-acetate; 4beta,9alpha,12beta,13alpha,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; PMA; TPA
Molecular Formula: C36H56O8
Molecular Weight: 616.83
Linear Structural Formula: C36H56O8
MDL Number: MFCD00036736
Purity: >=99% (HPLC)
Storage: -20C
Application: Suitable for
•molecular biology studies as standard
•analytical studies of tumor promoters
•promotion of cell growth
Biochem Physiol Actions: Potent tumor promoter; activates protein kinase C in vivo and in vitro.
Grade: for molecular biology
Assay: =99% (TLC)
Form: powder
Solubility: DMSO: soluble (DMSO solutions can be stored dark at -20 °C for at least six months.); ethanol: soluble
Storage Temp.: -20°C