Synonyms: (SP-4-3)-Diamminechlorido(phenanthridine)platinum(II) nitrate; PhenPt; cis-[Pt(NH3)2(phenanthridine)Cl]NO3
Molecular Formula: C13H15ClN4O3Pt
Molecular Weight: 505.81
Linear Structural Formula: C13H15ClN4O3Pt
Purity: >97% (NMR)
Storage: 2-8C
Biochem Physiol Actions: Phenanthriplatin is a cationic monofunctional DNA-binding platinum (II) complex with significantly greater anticancer activity (IC50 in muM = 0.035/Ntera2, 0.22/A549, 0.30/HeLa, 0.59/U2OS, 0.74/PC3, 0.94/MCF7, 2.02/HT29; 72 h, MTT assay) than cisplatin, oxaliplatin, and pyriplatin. Enhanced cellular uptake due to its hydrophobic phenanthridine ligand as well as more rapid DNA covalent-binding activity both contribute to its superior anticancer efficacy. Phenanthriplatin binds more effectively to 5'-deoxyguanosine monophosphate than to N-acetyl methionine, whereas pyriplatin reacts equally to both.