Synonyms: 8-(5-Chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5,dihydro-1H-benzo[g]indazole-3-carboxamide; PHA-00767408; PHA-767408
Molecular Formula: C29H27ClFN7O2
Molecular Weight: 560.02
Linear Structural Formula: C29H27ClFN7O2
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: PHA-408 is a potent, selective I kappa B-kinase 2 (IKK-2) inhibitor. PHA-408 is a tight binding, ATP competitive IKK-2 inhibitor with greater than 350-fold selectivity for IKK-2 vs IKK-1 (IC50 values of 10-40 nM at IKK-2 vs 14 muM at IKK-1). PHA-408 was shown to suppress inflammatory cellular events, and to reduce inflammation in animal models of arthritis.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.