Synonyms: 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide; PF-06650833
Molecular Formula: C18H20FN3O4
Molecular Weight: 361.37
Linear Structural Formula: C18H20FN3O4
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). IRAK4 kinase is important in innate immunity, involved in initiating signaling from Toll-like receptors and members of th einterleukin-1 receptor family. IRAK4 kinase is an attractive target for the treatment of various diseases associated with deregulated inflammation, such as rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, and systemic lupus erythematosus. PF06650833 has been investigated for treatment of lupus.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.